Mango–Probiotic Combo Linked to Better Brain Function and Lower Inflammation

The study found that consuming fresh mango alongside probiotic supplements on a daily basis can lower inflammatory markers and enhance certain cognitive functions, especially in people with overweight or obesity. Researchers reported that this dietary combination was associated with measurable improvements in both metabolic and cognitive health indicators.

Participants aged between 18 and 65 were enrolled in the study and divided into two groups. One group consumed 400 grams of mango daily together with probiotics, while the control group consumed mango with a placebo.

The results showed that overweight participants who received the mango–probiotic combination experienced a reduction in levels of the pro-inflammatory cytokine TNF-α, along with a modest improvement in memory performance. In contrast, participants with normal body weight showed enhanced attention and faster information-processing speed when consuming the same combination.

The researchers attribute these effects to polyphenolic compounds found in mango, known as gallotannins, which possess strong antioxidant and anti-inflammatory properties. In individuals with obesity, the bioavailability of these compounds is typically reduced.

However, probiotics appear to enhance their conversion into active metabolites and improve the composition of the gut microbiota. This includes an increase in beneficial bacterial groups such as Lactobacillus and Lachnospiraceae, which are linked to immune support and overall health.

According to the research team, the findings from this pilot study indicate that combining mango with probiotics could represent an effective, natural strategy to reduce inflammation and support cognitive function in individuals with metabolic disorders.