Iranian Scientists Make Nanobiosensor for Simple, Fast Detection of Sepsis Biomarkers
The researchers, within the framework of a doctoral thesis, have managed to design and study a nano-biosensor based on microfluidic paper that can successfully identify and quantify the two biomarkers of sepsis, the CRP and IL-6.
“The system designed in this doctoral thesis includes a nanobiosensor based on aptamers which enjoys a high potential in detecting target proteins. This nanobiosensor is completely specific and has high reproducibility and stability,” said Ali Hossein Rezayan, a professor of the department of nanobiotechnology and biomimetics of the faculty of Biological Sciences Engineering.
He added that gold nanoparticles are used in this sensor and can create different colors in different states with their special optical properties.
“Therefore, by checking the color of the results, the concentration of the target protein in the plasma is determined,” Rezayan explained.
“One of the important achievements of this thesis is that sepsis can be diagnosed quickly and relatively accurately without the need to complex and time-consuming devices by performing this test,” he said.
Sepsis is the body's extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Most cases of sepsis start before a patient goes to the hospital.
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