Bioactive Material from Fish Waste Promotes Bone Regeneration

According to the research team, the newly developed material merges seamlessly with the patient’s body and promotes natural healing processes, providing a foundation for the growth of new bone. The innovation could enhance the effectiveness of dental procedures, facial and jaw surgeries, and the treatment of bone injuries.

The material is based on marine collagen extracted from jellyfish biomass and the skin of pike-perch fish (Sander). It is hypoallergenic, infection-safe, and chemically neutral, making it highly compatible for medical use. Additionally, utilizing fish industry byproducts adds economic and environmental value to the technology.

One of the main challenges the team faced was connecting the collagen to the bone’s mineral matrix without damaging its natural structure. Comparative tests showed that the biocompatible EDC/NHS cross-linking system outperforms the traditional glutaraldehyde method by preserving the collagen’s natural structure and improving material stability within the body.

To further enhance durability, hydroxyapatite—a phosphate-based mineral—was incorporated into the material. This development is particularly significant given the recent rise in bone repair and dental implant procedures, highlighting its potential impact on regenerative medicine and clinical applications.