Rapid-Release Oral Nano-Tablet Produced in Iran to Control Blood Pressure

The newly designed nano-product made by the Iranian scientists may be able to solve the common problem of blood pressure pills as they dissolve within a short time as soon as they are placed on the tongue.

Researchers at Tarbiat Modarres University, led by Fariba Ganji in collaboration with Masoumeh Nasrollehzadeh, Arezou Soroushnia and Engineer Zahra Sabbaqi ​​Kalayee, succeeded in developing a product that can overcome many of limitations by producing a rapid-dissolving oral film of captopril based on drug nanoparticles.

These films, which are designed based on rapid-release polymer film technology, have a very small thickness and dissolve within a short time as soon as they are placed on the tongue. The more important point is that the structure of these films contains the drug captopril in the form of nanoparticles. 

The presence of nanoparticles increases the contact surface of the drug with the oral environment, resulting in its faster and more effective absorption by the body. This unique feature allows the therapeutic effect of the drug to occur in a much shorter period of time and patients have a more comfortable and effective consumption experience.

Oral films have several advantages compared to sublingual tablets. First, due to their thinness, they open faster and create a more pleasant feeling for patients. Second, the risk of choking and problems caused by swallowing tablets is eliminated in this technology. Third, unlike traditional solid drugs, they do not require special containers or complex storage conditions and are more stable against environmental factors. Also, the use of oral films makes the high precision required in the use of small sublingual tablets unnecessary.

In a relevant development in 2023, technologists at a knowledge-based company that operates in the field of medical equipment had also succeeded in producing Holter blood pressure devices for long-term monitoring of the electrocardiogram (electrical signals) in the heart.

Mohsen Avesta, the managing director of he knowledge-based company Kawshgaran Teb Kharazmi announced the success of Iranian technologists in their firm in designing and producing Holter heart and blood pressure devices.

A Holter blood pressure device monitors electrocardiogram (electrical signals) in the heart and records the changes in blood pressure over a 24-hour period. Holter monitoring of blood pressure evaluates the patient’s blood pressure levels during that period in the normal environment and activities of the patient outside the doctor’s office. The investigation is necessary in case of elevated blood pressure readings to rule out or confirm the diagnosis of hypertension and to evaluate treatment outcomes of previously diagnosed hypertension.

According to Avesta, their company has also succeeded in producing blood pressure analysis and online blood pressure analysis software, with the capability to display and analyze long-term blood pressure data at high speed, the capability to connect to a blood pressure Holter device using a USB port, automatically identify abnormal blood pressure fluctuations, and display reports. A complete set of blood pressure data includes time charts and detailed analysis, the capability to analyze blood pressure data to identify normal and abnormal blood pressure patterns, etc.

“Electrocardiogram (heart tape) analysis software with a simple and understandable user interface, advanced algorithms for analyzing the recorded data. It has the capability to view the results graphically and numerically, the capability to transfer the recorded data to other medical software, etc. It is developed by the engineers at this knowledge-based company,” he went on to say.

4155/v