Iranian Scientists Produce Rapid-Release Oral Nano-Tablet to Control Blood Pressure

A newly designed nano-product produced by the Iranian scientists may be able to solve the common problem of blood pressure pills as they dissolve within a short time as soon as they are placed on the tongue.

Researchers at Tarbiat Modarres University, led by Fariba Ganji in collaboration with Masoumeh Nasrollehzadeh, Arezou Soroushnia and Engineer Zahra Sabbaqi ​​Kalayee, succeeded in developing a product that can overcome many of limitations by producing a rapid-dissolving oral film of captopril based on drug nanoparticles.

These films, which are designed based on rapid-release polymer film technology, have a very small thickness and dissolve within a short time as soon as they are placed on the tongue. The more important point is that the structure of these films contains the drug captopril in the form of nanoparticles. 

The presence of nanoparticles increases the contact surface of the drug with the oral environment, resulting in its faster and more effective absorption by the body. This unique feature allows the therapeutic effect of the drug to occur in a much shorter period of time and patients have a more comfortable and effective consumption experience.

Oral films have several advantages compared to sublingual tablets. First, due to their thinness, they open faster and create a more pleasant feeling for patients. Second, the risk of choking and problems caused by swallowing tablets is eliminated in this technology. Third, unlike traditional solid drugs, they do not require special containers or complex storage conditions and are more stable against environmental factors. Also, the use of oral films makes the high precision required in the use of small sublingual tablets unnecessary.

In a relevant development in December, a technological company in Iran had also succeeded in producing a new type of probiotic cookie that easily restores the beneficial bacteria lost in the intestine and prevents diabetes, blood pressure, and cancer.

“Our company is health-oriented, and one of its products is called a probiotic cookie. Of course, we have also produced a soft drink that does not have the side effects of existing soft drinks,” Mohammad Salaminia, the managing director of the company stationed at the incubator center of Islamic Azad University’s Sabzevar branch, told ANA.

Noting that the probiotic cookie product has been patented, he said, “Our target audience is all people. In addition, diabetics, blood pressure patients, and other patients can use the probiotic products manufactured by our company.”

“By placing beneficial bacteria in the probiotic cookie which requires special technology, we microencapsulate the bacteria in the laboratory, cook it at high temperature, and then make it available to the public. In this way, the bacteria we have lost are re-established in the intestines and prevent diseases like diabetes, high blood pressure, and cancer,” Salaminia said.

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