Could Simple Vitamin Reverse World’s Most Common Liver Disease?
Roughly 30% of people worldwide are affected by metabolic-associated fatty liver disease (MASLD), a condition that until recently lacked targeted therapies. In an important breakthrough, scientists have identified a genetic factor that worsens the disease, and notably, the FDA-approved compound shown to be most effective against this factor is vitamin B3, the journal Metabolism reported.
A global first was achieved by a collaborative research group led by Professor Jang Hyun Choi of the Department of Life Sciences at UNIST, together with Professor Hwayoung Yun from the College of Pharmacy and Research Institute for Drug Development at Pusan National University (PNU) and Professor Neung Hwa Park from Ulsan University Hospital (UUH). Their work revealed the critical role of microRNA-93 (miR-93), a molecule expressed in the liver, as a genetic regulator influencing the onset and progression of MASLD.
MiR-93 is a type of RNA found in hepatocytes that suppresses the activity of specific target genes. Researchers detected unusually high levels of miR-93 in both human patients with fatty liver disease and in experimental animal models. Molecular studies showed that miR-93 drives lipid buildup, inflammation, and fibrosis by blocking the expression of SIRT1, a gene essential for regulating lipid metabolism in liver cells.
When scientists used gene-editing techniques to block miR-93 production in mice, they observed major reductions in liver fat accumulation, along with improved insulin sensitivity and liver function markers. In contrast, mice engineered to overexpress miR-93 displayed more severe impairments in liver metabolism.
Furthermore, screening 150 FDA-approved drugs revealed that niacin (vitamin B3) most effectively suppresses miR-93. Mice treated with niacin showed a significant decrease in hepatic miR-93 levels and a notable increase in SIRT1 activity. The activated SIRT1 restored disrupted lipid metabolism pathways, thereby normalizing liver lipid homeostasis.
The research team explained, “This study precisely elucidates the molecular origin of MASLD and demonstrates the potential for repurposing an already approved vitamin compound to modulate this pathway, which has high translational clinical relevance.”
They added, “Given that niacin is a well-established and safe medication used to treat hyperlipidemia, it holds promise as a candidate for combination therapies targeting miRNA pathways in MASLD.”
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