Iran Mass-Producing CDP Device for Detection of Surgical Margins of Cancerous Tumors

"CDP is the first completely Iranian cancer surgery device in the world, and so far 20 devices have been delivered to medical centers or are being delivered," said Mohammad Abdol Ahad, the head of the Electronic Cancer Research Institute of the University of Tehran.

Noting that the CDP is capable of identification of infected margins and involved lymph nodes during surgery with the help of electrical nanostructure sensor, he said that the CDP is the first completely Iran-made cancer surgery device in the world.

“It took 8 years since the formation and proof of the initial scientific idea based on the electrical measurement of cell metabolism to the final clinical product,” Abdol Ahad said.

He underlined that the Iran-made CDP system has several US-granted patents and more than 11 articles in prestigious international journals in various fields from bioelectronics to surgery with impact factors of above 10.

The Iran-made CDP device displays the results to the surgeon during surgery in real time.

“The device is a real-time Cancer Diagnostic Probe which helps the surgeons detect cancerous cells during surgery and improves the accuracy of diagnosis,” Hani Shahshahani, the managing director of the knowledge-based Nano Hesgarsazan Salamat Asia company, said.

He explained that the device is mainly used in treatment and diagnosis of breast cancer, and noted, “We continue our studies and efforts to obtain the license for using the CDP in other cancers too.”

“The device is used for real-time diagnosis of surgical margins in patients who are candidates for breast cancer surgery during surgery and after tumor removal,” Shahshahani said, adding that it helps the surgeon to find the surgical margins of the cancerous tumors during surgery and it will ensure the patients that he/she will not see cancer recurrence in the near future.

He noted that the Indian delegation became familiar with the Iran-made CDP device during a visit to Iran, and underlined their intention to import it.

The plan to sell the CDP device to the Indian group will be in a stair-step model, and initially 10 devices will be used in 10 hospitals in India and in the next stages, the number of devices will increase and eventually several hundreds of CDP devices will be supplied to India.

A CDP system diagnoses the presence of pre-neoplastic/neoplastic cells in either internal or external margins of the cancerous tissues of patients during breast cancer surgery. The system lively determines the H2O2 released from cancer or atypical cells, through reverse Warburg effect and hypoxia assisted glycolysis pathways, in quantitative electrochemical manner.

Checking the cavity-side margins during surgery for breast cancer patients is critical to ensure the definitive removal of suspicious and high-risk lesions with minimal damage to normal tissue. Remaining cancer cells in the breast causes re-surgeries and inevitable post-surgical treatments, which will have several side effects.

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