Nanomedicine Production Platforms in Iran

There are several other important platforms that are used in the world to produce nanomedicine, but we do not have any products with these platforms in Iran. Dendrimers, viral proteins, virus-like particles and mRNA/siRNA are among these important platforms that can be used for the production of nanomedicine in the country with research and development.

The review of scientific information shows that the three platforms Tissue-targeted delivery, cell-derived vehicles and Targeted degradation have a high potential for the production of nanomedicine, although they have not yet been used for the production of commercial medicine, neither inside nor outside the country.

The total value of drugs imported into Iran is less than $2 billion. Most of the drugs used in the country are produced inside the country. In the meantime, 97% of the medicine used in the country are domestically produced and a small portion of the drugs is being imported.

The following is a review of some Iranian nanomedicines, their platforms, as well as their prices compared with foreign-made equivelants:

Sina Doxosum is an anti-tumor medication used to treat metastatic breast cancer, especially in patients with or without cardiac problems. Manufactured by Exir Nano Sina, it is an antitumor drug that is used in the treatment of metastatic breast cancer, especially in patients who are exposed or have heart problems, as well as in the treatment of advanced ovarian cancer. The prices of drug is $ 65 in the international markets and the domestically produced product is offered to the market for the 750,000 tomans ($13).

Paclinab anticancer nanomedicine, which is a medicine for the treatment of cancers such as breast, lung and pancreas, was produced by Nano Daru Pharmaceutical Co. By penetrating the cancerous tissue, this nanomedicine prevents the progress of the tumor and destroys the cancerous tissue. The platform used for this nanomedicine is a protein-drug conjugate. Its global market value is 1.2 billion dollars. The price of the drug at the international markets is $ 80 dollars while the Iranian-made products’s price is 1,800,000 tomans ($35).

Padynex is an antibody-drug conjugate developed to fight breast cancer. The global market value of this drug in 2021 was around $2.1 billion, The price of the drug internationally is $3,950 and the domestic sample cost 9 million tomans ($180).

Depostiva contains triamcinolone acetonide loaded inside polymeric microspheres that aim to relieve knee pain. The platform of this drug is antibody-drug conjugate. The price of the foreign -made product of the drug is $665, while this Iranian drug costs 438,000 tomans (less than 1$0).

Sinampholeish is a nanomedicine that uses nanoliposome technology that is prescribed for the treatment of Leishmania.

Aprepitant is a medicine that has benefited from the nanocrystal platform, which is used to reduce nausea after chemotherapy. The total value of this drug is $127 million in the global market.

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