Iranian Company Produces 1st Molecule of Drug to Reduce Kidney Transplant Rejection

“This drug, which is prescribed in kidney transplants to reduce the body's immune system's reaction, was previously imported into the country, and its indigenization, in addition to saving $3.5 million, is considered an important step in the country's pharmaceutical self-sufficiency,” said Fazlollah Heydarnejad.

Noting that kidney transplant disease is very common in the country, and the human body usually reacts and rejects transplanted tissues when exposed to them, he said, “Therefore, the activity of the body's defense system should be reduced so that B and T lymphocyte cells decrease and the transplanted organ can adapt to the body and be recognized as a part of the body.”

Heydarnejad explained that the drug Sirolimus is prescribed after transplant surgery, adding, “When an organ enters the body, the body begins to attack it in a similar way to an antigen-antibody reaction, and the number of white blood cells increases, which results in damage to the connective tissue. To prevent this from happening, it is necessary to reduce the number of lymphocytes.”

“This drug is used with corticosteroids and is not used alone. It is also used in combination with cyclophosphamide drugs, and is actually considered a type of combination therapy,” he said.

In a relevant development in 2023, researchers of a knowledge-based company in Iran had also managed to produce dialysis filters for chronic kidney patients and succeeded in meeting the country's needs to the product.

Secretary of the Knowledge-Based Economy Development Department of the Iranian Vice-Presidency for Science, Technology and Knowledge-Based Economy Mostafa Qaneyee visited a knowledge-based company that produces dialysis filters for kidney patients during a trip to Alborz province.

This knowledge-based company, as the parent company, has put the production of dialysis filters on its agenda.

It produces a wide range of dialysis filters in low-flux and high-flux types and is now considered as one of the producers with expertise and experience in production of dialysis filters.

The filters produced by the knowledge-based company are produced in Iran in accordance to the international standards and have ISO 13485 (European Union) standards.

4155/v