Six Months in Space Causes '10 Years’ Worth of Bone Loss

Based on the study, during space missions, astronauts can experience a loss of some of the inner structural support in their bones. This leaves those bones less dense than before liftoff.

Bones “are a living organ,” notes Leigh Gabel. She’s an exercise scientist at the University of Calgary in Canada. Our bones are also “constantly remodeling,” she points out. But in the microgravity of space, bones will lose some of their strength.

Gabel was part of a team that tracked 17 astronauts. Each of these 14 men and three women had spent from four to seven months in space. The team used a type of computed tomography to measure the 3-D structure of bone on a fine scale. They focused on the structure of the tibia (in the lower leg) and radius bone (in the lower arm). This imaging revealed details on a scale of 61 micrometers. That’s finer than the thickness of a human hair.

The researchers took images of the bones four times — before spaceflight, then when the astronauts returned home from space, and again six months and one year later. From these pictures, Gabel’s team calculated an astronaut’s bone strength and density at each of those times.

Astronauts in space for less than six months regained their preflight bone strength after a year back on Earth. But those who stayed in space longer suffered permanent bone loss in their shinbones, or tibias. That loss was equivalent to a decade of aging. The lower-arm bones, or radii, showed almost no loss. That was likely because these aren’t weight-bearing bones on Earth, Gabel explains. In fact, those arms can get a bigger workout in space than on Earth as astronauts use them to navigate around their craft by pushing off handles and doorways.

Increasing weight-lifting exercises in space could help alleviate bone loss in the legs, said Steven Boyd. He’s also a Calgary exercise scientist. “A whole bunch of struts and beams all held together give your bone its overall strength,” said Boyd. “Those struts or beams are what we lose in spaceflight.” Once these microstructures (called trabeculae) are lost, you can’t rebuild them, he says. You can, however, strengthen the remaining ones. And upon return to Earth’s gravity, the remaining micro-structures did thicken, Gabel’s team found.

While bones can likely survive spaceflight longer than a year or two, Boyd and his co-workers want to know what happens once those bones get back to Earth’s gravity. “The question is,” he says, “Do they turn to jellyfishes?”

“With longer spaceflight, we can expect bigger bone loss — and probably a bigger problem with recovery,” said physiologist Laurence Vico. Not part of the study, she works at the University of Saint-Étienne in France. The new data are especially concerning for long missions, such as a trip to Mars. It would last at least two years. Vico adds that space agencies should also consider other bone health measures, such as nutrition, to reduce bone loss and increase bone formation. “It’s probably a cocktail of countermeasures,” Vico said, that will be needed.

Gabel, Boyd and their colleagues hope to learn more about how bones change after spending even more time in space. As part of a planned NASA project, they will study the effects of a year in space on more than a dozen systems of the body. Said Boyd: “We really hope that people hit a plateau — that they stop losing bone after a while.”

4155